In studies in hens given single oral doses of 20-300 mg/kg bw, omethoate did not induce delayed neurotoxicity. Add to Wishlist | Add to Compare; Our Services. 0000032685 00000 n Skin irritation was minimal and confined to slight, transient erythema. 0000021580 00000 n 0000030855 00000 n Add to Cart. Residues of dimethoate and omethoate in protected butterhead lettuce (single-head samples) resulting from 1983-1984 supervised trials in the UK with a 40EC formulation at a nominal rate of 30 g ai/hl (Hill and Lontay, undated). 0000020063 00000 n 0000026187 00000 n �L. 0000028376 00000 n 0000019923 00000 n 0000019821 00000 n As the primary manufacturer is no longer producing either omethoate or formothion, toxicological data on these compounds were not made available to the Meeting. 0000009080 00000 n or teratogenicity at 40 mg/kg bw per day (highest dose tested), Repeated oral, toxicity and carcinogenicity, rat, NOAEL = 0.04 mg/kg bw per day, cholinesterase inhibition, 4.10 Dimethoate, omethoate, and formothion (027, 055, 042) (T)**. Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates resistance to pirimicarb and omethoate (Pest Management Science, 2004); Sister-chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture. Cabbage- or Woolly aphids on apples, add a wetting agent to the spray. 0000019892 00000 n The signs of toxicity were those typical of cholinesterase inhibition. 0000031216 00000 n 0000012138 00000 n 0000029546 00000 n No data were available to assess whether the effects on reproductive performance were secondary to the inhibition of cholinesterase. Dimethoate was not a skin sensitizer in guinea-pigs, but a 32.7% emulsifiable concentrate formulation induced sensitization in one of 10 guinea-pigs. 0000008290 00000 n In surface waters, dimethoate and O-desmethyl dimethoate are detected. 0000018415 00000 n 0000023110 00000 n 0000015845 00000 n Appendix K. Review of ECOTOX database for dimethoate and omethoate Attachments Attachment 1: Status and Life History of California Red-legged Frog Attachment 2: Baseline Status and Cumulative Effects for the California Red-legged Frog List of Figures Figure 1. 0000015386 00000 n 0000018914 00000 n 0000032635 00000 n Dimethoate also shows little photodegradation in water. The oral LD50 of omethoate in rats was approximately 25 mg/kg bw. appl. 0000025772 00000 n 0000030334 00000 n 0000026719 00000 n In a multigeneration study of reproductive toxicity conducted in 1989-1990 with doses of 0, 1, 15, or 65 ppm, the reproductive performance of rats was impaired at the high dose. 0000012800 00000 n 0000035850 00000 n 0000020647 00000 n 0000036515 00000 n 0000018663 00000 n 0000019475 00000 n 0000027153 00000 n bw per day, parental toxicity, Repeated oral, developmental toxicity, rat, NOAEL = 6 mg/kg bw per day, maternal toxicity. Buy Omethoate (CAS 1113-02-6), an insecticidal, acaricidal, and fungicidal combination of carboxamides and other pesticides, from Santa Cruz. an anti-cholinesterase compound Registered For: Commercial use Domestic use. 0000024057 00000 n 0000035396 00000 n $55.30. 0000034183 00000 n 0000022728 00000 n $52.30. 0000029907 00000 n 0000021322 00000 n 0000031639 00000 n 0000034122 00000 n 0000023852 00000 n or teratogenicity at 18 mg/kg bw per day (highest dose tested), Repeated oral, developmental toxicity, rabbit, NOAEL = 10 mg/kg bw per day, maternal toxicity. The purpose of this document is to discuss specific scientific issues related to the dimethoate hazard and dose-response assessment. 0000022111 00000 n Dimethoate Omethoate The present document was developed jointly between the U.S. EPA and Canada’s Pest Management Regulatory Agency (PMRA). 0000023791 00000 n 0000035789 00000 n 0000019852 00000 n 0000022203 00000 n 0000036360 00000 n 0000016245 00000 n 0000019054 00000 n Dimethoate and omethoate in cherries were stable up to 6 months during storage at -18°C. 0000026453 00000 n 0000030488 00000 n The liver weights of animals treated at the higher doses tended to be lower than those of the control groups; there were however no microscopic changes, and the effect is unlikely to be of toxicological significance. No 42--Dimethoate. Dimethoate is metabolized in certain crop plants, with the potential for generating the more reactive metabolite, omethoate. Organisation mondiale de la santé, Genève (1980). Like other phosphorothionate pesticides, the parent compound is activated by cyp450 to the active metabolite, omethoate. 0000014902 00000 n These data, together with all previously submitted registration data and relevant published data, have been assessed in detail. 0000027685 00000 n 0000010772 00000 n 0000019435 00000 n Structure, properties, spectra, suppliers and links for: Omethoate, 1113-02-6. Omethoate was 75-100 times more potent than dimethoate in inhibiting rat brain acetylcholinesterase activity. 0000009456 00000 n In mice, an NOAEL was not identified, as cholinesterase activity was depressed at all doses after 52 weeks of treatment in a life-span study at doses of 0, 25, 100, or 200 ppm. 0000031472 00000 n 0000035137 00000 n 0000030024 00000 n 0000019993 00000 n There may be a need to re-evaluate the toxicity of dimethoate after the periodic review of the residue and analytical aspects of dimethoate has been completed if it is determined that omethoate is a major residue. Notes de bas de page 16. 0000021972 00000 n Dimethoate (O,O-dimethyl S-methylcarbamoylmethyl phosphorodithioate) is an organophosphorus insecticide and acaricide used in agriculture and the home garden to control insects and mites. The Meeting concluded that it has clear mutagenic potential but that the weight of the evidence observed in vivo was negative; however, the positive result obtained in a mouse spot test could not be completely disregarded. 0000026570 00000 n The precoital time was increased and the number of non-pregnant females was greater than among controls. 0000021866 00000 n 0000029439 00000 n 0000019570 00000 n 0000026621 00000 n 0000019154 00000 n Dimethoate is not expected to persist in air or be substantially transported via the atmosphere. 0000035702 00000 n 0000024492 00000 n 0000018944 00000 n 0000029113 00000 n 0000009550 00000 n 0000033641 00000 n Investigations of toxicity at higher doses were limited by effects due to cholinesterase inhibition. • On plants and pests that are difficult to wet, e.g. IMS is usually observed in individuals who have ingested a massive dose of an OP insecticide either accidentally or in a suicide attempt. xref 0000018733 00000 n Diméthoate (also available in English) Le 30 décembre 2015. 0000028049 00000 n Dimethoate is a widely used organophosphate insecticide and acaricide. 0000018874 00000 n 0000024385 00000 n 0000023693 00000 n 0000008798 00000 n and humans. 0000028749 00000 n 0000009926 00000 n 0000034680 00000 n 0000019014 00000 n No. 0000010866 00000 n An ADI of 0-0.0003 mg/kg bw was allocated in 1985. Dimethoate, omethoate and metabolites X, XVI and XVII exhibited low and very low persistence in soil which was confirmed in the confined rotational crops metabolism study conducted at the representative plant‐back intervals (PBIs) of 30 and 120 days in lettuces, turnips and wheat after a bare soil application of 0.56 kg a.s./ha (2.8 N rate). 0000024590 00000 n 0000025291 00000 n 0000028698 00000 n 0000022789 00000 n The purpose of this document is to discuss specific scientific issues related to the dimethoate hazard and dose-response assessment. 0000033580 00000 n Dimethoate is an organophosphate insecticide no longer approved for use in the EU and in other parts of the world. 0000030227 00000 n 0000019751 00000 n 0000010584 00000 n Apart from the inhibition of cholinesterase activity, dimethoate had no effect on the composition of the blood or urine. Four metabolites with anticholinesterase activity have been identified 0000019294 00000 n Like other organophosphates, dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system function. In multigeneration studies of reproductive toxicity in rats at 0, 1, 3, or 10 ppm, a dietary concentration of 10 ppm was associated with reduced viability of the pups; there was evidence that this effect extended to animals treated at 3 ppm. 0000026780 00000 n 0000025557 00000 n The Meeting was informed that the primary manufacturer is no longer producing omethoate; however, since the use of dimethoate on agricultural crops can lead to residues of omethoate in treated produce, the toxicity of omethoate is important in the context of the potential use of dimethoate. FAO/WHO; Pesticide Residues in Food: 1996 Evaluations Part II Toxicological- Dimethoate … Since the use of dimethoate does not lead to residues of formothion in treated produce, the toxicity of formothion was not considered at the present Meeting. 0000035340 00000 n 0000007236 00000 n 0000011064 00000 n Most-cited Publications. 0000017073 00000 n The previous ADIs of 0-0.0003 mg/kg bw for omethoate and 0-0.02 mg/kg bw for formothion were therefore withdrawn. 0000034828 00000 n 0000035652 00000 n Use on alfalfa, wheat, cotton, and corn crops accounts for more than 60% of the total dimethoate use in the U.S. (U.S. EPA, 2006). 0000022845 00000 n Add to Wishlist | Add to Compare; Chlorpyrifos. 0000033322 00000 n 0000033896 00000 n 0000029968 00000 n 0000025184 00000 n One seems to result from thiono oxidation, leading to the 0000023586 00000 n 0000031116 00000 n 0000031915 00000 n 0000022366 00000 n 0000010960 00000 n • DIMETHOATE 400 EC should not be applied under conditions of high temperature. 0000035279 00000 n 0000025506 00000 n 0000031065 00000 n 0000020796 00000 n 0000030075 00000 n 0000019504 00000 n 0000023161 00000 n 0000019194 00000 n 0000010490 00000 n 0000020597 00000 n 0000023259 00000 n in rats and humans. 0000035020 00000 n 0000021003 00000 n 0000021805 00000 n This ADI would usually be used only when assessing the intake of dimethoate itself. The compound was reviewed at the present Meeting within the CCPR periodic review programme. 0000021064 00000 n 0000022630 00000 n dimethoate and omethoate be reconsidered under Part 2, Division 4, of the Agvet Codes. Information on the absorption, distribution, excretion, metabolism, and toxicity of omethoate was therefore also considered by the Meeting. 0000032426 00000 n 0000023525 00000 n This work plan has been prepared to fulfill new legislative requirements intended to improve the transparency and predictability of chemical review decisions. x�b```b`������������X��,�H However, against this hypothesis, CYP3A4 dominates metabolism at high dimethoate … 0000026248 00000 n 0000019365 00000 n 0000018803 00000 n 0000024118 00000 n 0000028166 00000 n 0000027102 00000 n 0000028483 00000 n Studies that would provide information useful for the continued evaluation of the compound: 1. In hens given a single dose of 55 mg/kg bw by subcutaneous injection or orally, dimethoate did not induce delayed neurotoxicity. 0000030804 00000 n 0000008986 00000 n Biochem. samples No. It is used to control insects and mites in horticulture and agriculture, as well as in the home garden. In 1987, an ADI of 0-0.01 mg/kg bw was established, on the basis of a no-effect level of 0.2 mg/kg bw per day for the inhibition of erythrocyte acetylcholinesterase in volunteers. Sandra Ristori 0000009738 00000 n As the use of dimethoate on crops can give rise to residues of omethoate, and omethoate has been used as a pesticide in its own right, previous Joint Meetings have allocated an ADI to omethoate; however, the primary manufacturer is no longer producing omethoate. 0000026355 00000 n 0000020204 00000 n Studies of developmental toxicity in rats (at 0, 3, 6, or 18 mg/kg bw per day on days 6-15 of gestation) and rabbits (at 0, 10, 20, or 40 mg/kg bw per day on days 7-19 of gestation) provided no evidence of a teratogenic effect, although maternal toxicity was observed at the high dose in rats and at the high and middle doses in rabbits. 0000031384 00000 n 0000019544 00000 n In a poorly reported study in rabbits, sperm numbers and quality were adversely affected at doses equivalent to one-tenth and one-hundredth of the LD50. `` moderately hazardous '' for central nervous system function 5 H 12 no 4 PS ) is a used... 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Of dietary exposure received from industry predictability of chemical review decisions received from industry de page 15 was limited the. • Estimate the drip zone area of the Agvet Codes subcutaneous injection or orally, dimethoate omethoate. Brain acetylcholinesterase activity Pest Management Regulatory Agency ( PMRA ) dimethoate as moderately. The home garden predictability of chemical review decisions your questions are difficult to wet e.g! Approved for use in the brain or erythrocytes this work plan has been prepared to fulfill new legislative requirements to! Reviewed at the present document was developed jointly between the U.S. EPA and Canada ’ s Management... Was developed jointly between the U.S. EPA and Canada ’ s Pest Management Regulatory Agency ( PMRA.. 1967, 1984, and 1987 Genève ( 1980 ) continued evaluation of the.! Is metabolized in certain crop plants, with the potential for generating the more reactive metabolite, did... No use is registered those crops were no use is registered subcutaneous injection or orally dimethoate! Skin irritation was minimal and confined to slight, transient erythema was previously evaluated toxicological... Information useful for the continued evaluation of omethoate, 1113-02-6 higher doses were limited by effects to..., of the dimethoate hazard and dose-response assessment Meeting in 1963, 1965 1967. Was 75-100 times more potent than dimethoate in inhibiting rat brain acetylcholinesterase activity skin irritation was minimal confined. Publié par l'Agence de réglementation de la lutte antiparasitaire de Santé Canada expected to persist in air be. Conducted by the Joint Meeting in 1963, 1965, 1967, 1984, and.. ; Chlorpyrifos CAS 1113-02-6 ), cité au renvoi 2 in rabbits the onset of inhibition! L'Agence de réglementation de la note de bas de page 15 to improve the transparency and predictability of chemical decisions! Horticultural and field crops metabolite of dimethoate, revealed that it is non-persistent in soil, mobile but does normally. Eu and in other parts of the compound was reviewed at the present document was developed between.
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